What is ASC III™?
ASC III (Amplifier of Synthesis of Collagen III) it is a strengthener of synthesis of collagen, third generation. It is combination of matters, which activates work of fibroblast (basic cellular form of skin), which are responsible for the production of collagen the fibres of which are supported by a resiliency and elasticity of skin.
ASC III™ is a suspension of phospholipidic vesicular carriers, in which the external lipophilic wall contains the amphipilic Dipalmitoyl Hydroxyproline (DPHP).
ASC III™ selectively amplifies the biosynthesis of Collagen III in human skin. ASC III™ is a unique, which is hexagonally-pyramidal shaped; its membrane always shows angled structures.
INCI Name: Water, Lecithin, Dipalmitoyl Hydroxyproline, Phenoxyethanol, Tall Oil Sterol, Linoleic Acid, Tocopherol, Sodium Ascorbate, Methylparaben, Butylparaben, Ethylparaben, Propylparaben, Mannitol.
Product Attributes
Selectively increases Collagen III production with reduction in Collagenase activity.
Increase in Collagen production is due to induction of fibroblast activity and not due to fibroblast proliferation
Pronounced increase in thickness of keratinocyte layers as well as dermal/epidermal junction area. Reformation of collagen fibers in dermis
Significantly increase skin elasticity.
What happens when we age?
Among the numerous modifications of the extracellular matrix during aging, collagen synthesis shows a significant decrease during the aging process. The ratio of collagen synthesized in skin changes through out life. However, age-related decrease in the ratio of Collagen III / Collagen I is a dramatic one (Peter K. Mays, Jill E. Bishop and Geoffrey J. Laurent, Mechanisms of Aging and Development, 45 (1988). Page 203-212).
The reduction and alteration of the natural collagen support layer that lies beneath the skin cause facial lines and wrinkles. Creams and lotions can moisturize or exfoliate the surface of the skin, but they can't diminish the lines or wrinkles that are caused by the reduction and the alteration of the underlying collagen support.
How does ASC III™ Work?
In this method, the epidermis is separated from the dermis from a normal human skin sample. The epidermal cells (consisting mainly of keratinocytes) are then incubated in the culture media with ASC III™ thereby stimulating the production of cytokines. The keratinocyte supernatant culture containing the cytokines is collected, filtered, and then added to the fibroblast cultures. If the keratinocytes were stimulated successfully, they would synthesize cytokines, concomitantly triggering the fibroblasts to produce collagen. Our date shows that ASC III™ is increasing collagen III synthesis selectively in elderly fibroblasts by similar degrees as in new born cells even though basal levels of collagen synthesis are dependent.